Job Description

Job Summary

The Scadden laboratory is dedicated to discovering the principles governing blood cell production, with the ultimate goal of guiding the development of therapies for blood disorders and cancer. The Lab is seeking an experienced scientist to provide scientific and administrative leadership for three projects. The Research scientist will collaborate with the Principal Investigator to develop and execute complex and specialized research studies as part of an industry-sponsored collaboration. They will also collaborate with and manage other scientists recruited to work on the project.

Position Description

Independently lead and execute large-scale small molecule screens for hit identification and contribute to follow-up experiments throughout medicinal chemistry and lead optimization.

• Lead the development of assays for small molecule discovery
• Miniaturize and adapt cell-based and biochemical assays to automated screening systems
• Propose and develop innovative approaches to small molecule discovery based on the latest technologies and publications in the field
• Analyze, critically interpret and present data to industry partners, and recommend courses of action based on datasets and discussions with biologists and chemists.

Work with multi-scientist team to develop subcutaneous organoid with appropriate signaling molecules to improve t-cell reconstitution.

• Develop protocols to achieve reproducible organoids for large scale work in mice, humanized mice, and higher order species.
• Develop protocols to analyze T-cell recovery in higher order species
• Explore additional molecules to improve stem cell content in subcutaneous organoids to serve as a means to improve gene therapy induction in HSCs.

Basic Qualifications

MS in Biological/ Pharmaceutical Sciences or a related field with at least 7 years of hands-on experience in academic or pharmaceutical/biotechnology labs.

Additional Qualifications and Skills

• Experience in molecular biology techniques and deep understanding of normal and malignant hematopoietic biology are required.
• RNA/DNA extraction/purification and manipulation (e.g. enzyme digestion and modification, agarose gel electrophoresis, qPCR, RT-PCR)
• Taqman and gene expression analysis
• Flow Cytometry, SDS-PAGE and Western blotting
• Mammalian cell culture, genetic target modulation (siRNA, shRNA, CRISPR) via cell transfection and sterile technique
• Hematopoietic stem cell isolation and culture techniques.
• Lentivirus and adeno-associated virus production and cell transduction.
• Experience developing and optimizing enzymatic biochemical assays.
• Experience working with bone marrow transplants in mice is required.
• Good understanding of T-cell lineage and associated assays including TREC.
• Bone tissue image analysis ? microCT and histology/morphology
• Experience with high-throughput robotic platforms is a plus.
• Knowledge of the latest technologies and novel approaches to small-molecule drug discovery

Additional Information

We are unable to provide visa sponsorship for this position.


All formal offers will be made by FAS Human Resources

Benefits

We invite you to visit Harvard's Total Rewards website ( ) to learn more about our outstanding benefits package, which may include:

• Paid Time Off: 3-4 weeks of accrued vacation time per year (3 weeks for support staff and 4 weeks for administrative/professional staff), 12 accrued sick days per year, 12.5 holidays plus a Winter Recess in December/January, 3 personal days per year (prorated based on date of hire), and up to 12 weeks of paid leave for new parents who are primary care givers.
• Health and Welfare: Comprehensive medical, dental, and vision benefits, disability and life insurance programs, along with voluntary benefits. Most coverage begins as of your start date.
• Work/Life and Wellness: Child and elder/adult care resources including on campus childcare centers, Employee Assistance Program, and wellness programs related to stress management, nutrition, meditation, and more.
• Retirement: University-funded retirement plan with contributions from 5% to 15% of eligible compensation, based on age and earnings with full vesting after 3 years of service.
• Tuition Assistance Program: Competitive program including $40 per class at the Harvard Extension School and reduced tuition through other participating Harvard graduate schools.
• Tuition Reimbursement: Program that provides 75% to 90% reimbursement up to $5,250 per calendar year for eligible courses taken at other accredited institutions.
• Professional Development: Programs and classes at little or no cost, including through the Harvard Center for Workplace Development and LinkedIn Learning.
• Commuting and Transportation: Various commuter options handled through the Parking Office, including discounted parking, half-priced public transportation passes and pre-tax transit passes, biking benefits, and more.
• Harvard Facilities Access, Discounts and Perks: Access to Harvard athletic and fitness facilities, libraries, campus events, credit union, and more, as well as discounts to various types of services (legal, financial, etc.) and cultural and leisure activities throughout metro-Boston.

Work Format

On-Site





Commitment to Equity, Diversity, Inclusion, and Belonging
Harvard University views equity, inclusion, and belonging as the pathway to achieving inclusive excellence and fostering a campus culture where everyone can thrive. We strive to create a community that draws upon the widest possible pool of talent to unify this excellence while fully embracing individuals from varied backgrounds, cultures, races, identities, life experiences, perspectives, beliefs, and values.



EEO Statement
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law.

About Harvard University Faculty of Arts and Sciences

Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders in many disciplines who make a difference globally. The University, which is based in Cambridge and Boston, Massachusetts, has an enrollment of over 20,000 degree candidates, including undergraduate, graduate, and professional students. Harvard has more than 360,000 alumni around the world. The University has twelve degree-granting Schools in addition to the Radcliffe Institute for Advanced Study, offering a truly global education. Established in 1636, Harvard is the oldest institution of higher education in the United States.

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